Scientists Discover Unique Gene Variant That Protects Greek Village From Heart Diseases
They love their fat, they like their food, and they have no reason to fear the associated cardiovascular risks a little. Scientists have found a unique variant of gene protection between Mylopotamos indigenous, Creta normal, a remote village in Greece, which is believed to protect against cardiovascular risks and heart disease, despite its diet loaded with saturated animal fats.
The team of researchers at the Wellcome Trust Sanger Institute of UK researchers pointed out that the variant rs145556679 * is associated with lower levels of “bad” natural fats and “bad” cholesterol, factors that reduce the risk of cardiovascular disease.
The study published in the journal Nature Communications revealed that the special cardioprotective variant was found in people living in a somewhat isolated life, thriving on a diet high in animal fat.
For the study, the researchers performed a genetic profile of the population by sequencing the entire genome of 250 people. The team used the results to get a more detailed view of 3200 people for whom the above genetic information is known.
As part of their study, we discovered a new variant of the cardioprotective gene, which we did not know before cardioprotective qualities. Scientists also said that the variant may be almost unique to the people of Mylopotamos, adding that the results of the genome sequencing of a few thousand Europeans revealed that only one copy of this variant in a single person in Tuscany, Italy .
The team also found a distinct variation in the same gene associated with lower levels of triglycerides in the founding population of Amish in the United States.
Lorraine Southam of the Wellcome Trust Sanger Institute said: “We have been able to identify genetic variants that are more common than the cosmopolitan population, which increases our power to detect whether these variants are responsible for the disease.”
Stressing the Importance of Outcomes in the Isolated Population Southam said: “With populations isolated, we can have a unique view of rare genetic variants that play an important role in complex human diseases”
The team also studied a population isolated from the villages of the pomak mountain region in northern Greece, so the genetics examined approximately 1,700 people in the population and found four distinct genetic variants affecting diastolic blood pressure, fasting Blood glucose levels, white blood cells, and hemoglobin numbers.